The basis for life-long neurological competency is laid during the fetal and neonatal periods of development. Various factors do have an impact on the growing brain and subsequently determine long term development. Diseases that are caused in this critical period are associated with a severe burden to the individual but also to the society, and represent an unmet medical need. Currently, there is a lack of advanced analytical tools for detailed health status assessment in that vulnerable population that would allow personalized medicine to prevent long-term burdens.

By focusing on the feto-neonatal period of development, it is the objective of the present project (I) to improve traditional health assessment tools through artificial intelligent (AI) systems to continuously and accurately monitor neurodevelopment, (II) to develop advanced analytical tools to investigate further clinical factors impacting neurodevelopment and head growth, (III) to develop personalized strategies for preventing impaired head growth in the feto-neonatal period, and to finally (IV) develop personalized and smart therapeutic strategies for treating common head pathologies, namely cranial deformities.